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Design and development of vegetable capsule films from A. esculentus and carageenan mucilage polysaccharides
2nd International Conference & Expo on Biopharmaceutics and Biologic Drugs
September 14-16, 2016 San Antonio, USA
Archana G
Anna University, India
Posters & Accepted Abstracts: J Bioequiv Availab
Abstract:
Capsule is one of the most versatile routes of dosage forms in drug delivery. Gelatin was used to prepare capsule films since ancient times. Gelatin capsules had certain disadvantages like sensitivity to moisture, religious restrictions, special packaging which had lead to the establishment of synthetic polymers and/or plant-derived hydrocolloids for preparation of capsule materials. The main objective of this study is to prepare and characterize polysaccharide based empty vegetable capsule film materials from mucilage polysaccharides of A. cesculentus and carageenan. Mucilage polysaccharides were extracted from A. esculentus (upper crown head-biowaste) and red seaweeds by solvent extraction method at 85oC at 275 rpm/sec and purified. Capsule films were prepared by solvent casting method using A. esculentus and Carageenan mucilage polysaccharides dispersions. Empty capsule films were evaluated for surface morphology, mechanical properties. The mechanical properties of the film material were studied using an Instron Universal Testing Machine which indicated that the A. esculentus/carageenan polysaccharide blend films at the ratio of 0.5/0.5 had the highest tensile strength (TS) 6.8 Mpa and optimum % elongation 23% which was higher than the gelatin (control) film (pā?¤0.05). The in-vitro disintegration and dissolution time of empty capsule films from A. esculentus as well carageenan measured at different temperatures (25-45oC) and pH (4-8) was greater and desirable for both compared to that of gelatin capsule films. Therefore the above polysaccharides could act as potential agent in the development of various pharmaceutical ingredients such as empty capsule shell material, coating material with enhanced release rates, better patient compliance and effective therapy.
Biography :
Email: archanacbt1@gmail.com