Journal of Nanomedicine & Nanotechnology

Design and application of multifunctional stimuli-responsive systems for sensing and diagnostic

26^th International Conference on NANOMATERIALS

December 05-06, 2022 | Dubai, UAE

Helena Iuele

CNR NANOTEC Institute of Nanotechnology, Italy

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

Material science and materials customization helped overcoming many biological issues. Sensing materials are particularly relevant for the in-situ monitoring of 3dimensional cellular microenvironment alterations occurring both during physiological processes, such as tissue regeneration, and pathological processes, such as cancer evolution while therapy materials allow treating targeted cells with one or more contextual therapies controlling and modulating their duration in space and time. Herein, the synthesis and functionalization of materials with advanced properties will be described with a special focus on the properties they could offer for the aforementioned biomedical applications. Optical ratiometric micro-sensors designed to track spatio-temporal pH changes of the local cellular microenvironment are presented as example of sensing materials, in particular: (1) Capsules-based biosensors placed in mesenchymal stromal cell 3D scaffolds, (2) Highly sensitive silica-based biosensors tested with human colorectal carcinoma cells, (3) Silica- based fluorescent pH sensors embed into alginate-based three-dimensional microgels tumor models.
Recent Publications :
1. Helena Iuele, Nicholas Ling, Adam Hartland, (2021). Characterization of a green expanded DGT methodology for the in-situ detection of emerging endocrine disrupting chemicals in water systems, Sustainable Chemistry and Pharmacy, Volume 22, 100450, ISSN 2352-5541.
2. Helena Iuele, Alessio Bucciarelli, Nicholas Ling, (2022). Novel hyphenation of DGT in-situ passive sampling with YES assay to ascertain the potency of emerging endocrine disruptors in water systems in New Zealand, Water Research, Volume 219, 118567, ISSN 0043-1354.
3. Helena Iuele, Francesco Colella, (2022). A pH-sensor scaffold for mapping spatiotemporal gradients in three-dimensional in vitro tumour models, Biosensors and Bioelectronics, Volume 212, 114401, ISSN 0956-5663.

Biography :

Helena Iuele is a post-doctoral fellow at the Nanotechnology Institute of CNR (IT) within the ERC project Intercellmed. Her research is focused on the synthesis of optical sensors for the pH, O2 and K+ mapping in 3D in vitro tumor models. Previously, she was a post-doctoral fellow at Universidad Nacional de Colombia (CO) where she prepared new fullerene derivatives for applications in solar cells. In 2019, she completed her PhD in Chemistry at University of Waikato (NZ) where she monitored environmentally and ecotoxicologically carcinogenic endocrine disrupting chemicals. In 2015, she became a material specialist at IMaST Scarl (IT) and patented sensors for monitoring glucose, lactic acid and nicotine.