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Decoration of silica-based mesoporous nanoparticles with PEG and folic acid via disulfide bond for controlled doxorubicin delivery
Nanotechnology Congress & Expo
August 11-13, 2015 Frankfurt, Germany
Dai Hai Nguyen
Poster-Accepted Abstracts: J Nanomed Nanotechnol
Abstract:
Porous nanosilica (PNS) applied for drug controlled release have attracted more and more scientists due to their ordered large pore volume, high chemical and thermal stability, excellent biocompatibility, and versatile chemistry. Moreover, PNS is composed of highly ordered porous structures with uniform but adjustable pore size, which make it an excellent candidate for accommodating guest molecules, to provide a physical encasement that can protect the entrapped drugs from degradation and denaturization. However, the loading bioactive molecules would burst release from the unmodified PNS, and could not release in a controllable manner to precisely match the actual physiological needs at the proper time/site. Here, self-assembly folic acid-poly(ethyleneglycol)- adamantylamine (FA-PEG-ADA) functionalized PNS was fabricated by host-guest inclusion with cyclodextrin (CD) which modified on PNS via disulfide bond for targeted and controlled doxorubicin (DOX) delivery. The PNS prepared by so-gel method was formed with spherical shape and an average diameter of 40 nm determined by TEM. The drug loading efficiency and drug loading content of PNS-PEG/DOX were 51.4 ± 5.7% and 18.2 ± 1.3%, respectively. The release test showed that there were significant time prolongations of DOX release from the PNS-PEG/DOX compare to PNS/DOX and a considerable amount of DOX was released from PNS-PEG/ DOX after glutathione treatment. The MTT assay indicated that PNS was a biocompatible delivery vehicle which reduces the cytotoxicity of DOX. Furthermore, FA functionalized on PNS exhibited higher cellular uptake than unmodified particles. The results indicated that such PNS-CD/DOX/PEG have great potential as a novel drug delivery system for cancer therapy.