Brain Disorders & Therapy

Comparison of genomic alterations in untreated versus treated glioblastoma

International Conference on Neuro Oncology and Rehabilitation

July 21-22, 2016 Brisbane, Australia

Michele Aizenberg

University of Nebraska Medical Center, USA

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Glioblastoma (GBM) is a heterogeneous group of tumors despite a uniform histological diagnosis. The varied behavior and response to therapies is associated with the genomic alterations that exist within the tumors. Genomic profiling has been utilized to identify potentially actionable gene alterations in various cancers, including primary brain tumors. We aimed to illustrate that genomic alterations in recurrent GBM are distinct from the primary untreated tumor. Next-generation sequencing was performed on paired specimens from 10 glioblastoma patients. One patient had a second recurrence available for analysis resulting in 21 tumor specimens. We found that the somatic alteration profile differed between primary and recurrent GBM. As the specific alterations are identified and compared, further information will be gleaned about potential actionable alterations and guidance of therapy based upon these alterations.

Biography :

Email: maizenberg@unmc.edu