Journal of Bioequivalence & Bioavailability

Comparison of biological activities between synthesized ester derivatives and its parent compound Solanesol

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Sridevi.P, Rangarao.P and Bhagavan Raju.M

Scientific Tracks Abstracts: J Bioequiv Availab

Abstract:

T he new method was prepared for the extraction of pure solanesol by a safe, economic, ecofriendly and industrial viable process. Similarly six semi synthetic derivatives of solanesol were prepared with acceptable degree of purity, and their structures were elucidated with the help of spectral data. Biological studies of semi-synthetic compounds showed improved antioxidant and antimicrobial activity than solanesol. Experimental: Powdered tobacco leaves were treated with hexane and the residue obtained was treated with hot methanol (50-55 O C) to obtain crude Solanesol. To this 10% of methanolic KOH was added and heated at 55-60 O C for 4 hours. The solid obtained was collected; toluene was added and then distilled under vacuum. Then the solution was filtered using silica bed to obtain 90% pure-crude Solanesol.