Journal of Bioequivalence & Bioavailability

Clinical effectiveness of an inteferon beta 1a biosimilar: Results from an open-label, multicenter, observational study

International Conference and Exhibiton on Pharmaceutical Regulatory Affairs

6-7 September 2011 Baltimore, USA

Marcelo Kauffman, Gonzalez- Moron D, Rey R, Hess D, Sanchez Talavera J, Paredes M, Vrech C, Odoriz B, Bello R, Criscuolo M, Bercovich A and Diez RA

Posters: JBB

Abstract:

C urrent statistics from WHO indicate that more than 80% of the world?s population depends on traditional medicine which include plants and plant products for their health needs. Oxalis corniculata , a herbaceous plant is used for treatment of a variety of disorders specially diarrheal diseases, hemorrhage, antidotes of venomous snakes etc. by tribes of India. Th e objectives of the present study are to investigate the biochemical composition of Oxalis corniculata leaves and to investigate the antioxidan t as well as antimicrobial properties of methanolic extract of Oxalis corniculata leaves. Th e rutin and ferulic acid are present in the extract and had been detected by HPLC analysis. Total polyphenol and fl avonoid content were also measured. Reducing power, hydroxyl radical scavenging activity, FRAP assay, DPPH radical scavenging activity, fenton reaction, liposome oxidation, emulsion peroxidation were measured which showed that the extract have a high antioxidant activity. Methanolic extract of Oxalis corniculata also showed a protective eff ect on peroxide formation during heating and subsequent storage of heated oil. Antibacterial activity were evaluated by comparing minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against several pathogenic bacteria i.e. Staphylococcus aureus (ATCC 25922), Escherichia coli (ATCC 25923), Shigella dysenteriae 1 (SB 1), Shigella fl exneri2a (2457T), Shigella boydii (SB 5), Shigella sonnie (SB 6). Leaf extract showed signifi cant reduction of colonizing activity against Shigella fl exneri 2a (2457T) infection in suckling mice model. On the whole, it can be concluded that the nano-encapsulation of leaf extract of Oxalis corniculata could be used as a productive antioxidant and antimicrobial drug in future

Biography :

Sayani Mukherjee has completed her M.Sc in Physiology from Burdwan University, West Bengal, India and received gold medal. After completion of her master degree, she has joined as a Junior Research Fellow in the University of Calcutta and started work on development of drug from medicinal plants