Journal of Nanomedicine & Nanotechnology

Chirp coded excitation using nano particle for improving small animal imaging resolution

5^th International Conference on Nanotek & Expo

November 16-18, 2015 San Antonio, USA

Jian-Xing Wu1, 2

1National Synchrotron Radiation Research Center, Taiwan 2National Cheng Kung University, Taiwan

Posters-Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Nano particle techniques such as coded excitation methods have become popular in ultrasound imaging due to its capability to improve imaging resolution. The aforementioned techniques require the nano particle to efficiently oscillate by insonation with pulse transmission near to the resonance frequency of the contrast agents. However, for most commercial ultrasound contrast agents, they are originally designed to resonate at lower frequencies ranging and coded excitation methods, thus limiting the spatial resolution of imaging. To overcome this problem, the aim of this research is chirp coded excitation using nano particle as the trigger signal for raising signal energy in high-frequency ultrasound imaging system which can approach to best CTR (Contrast-to-Tissue Ratio), we can acquire the optimal frequency more precisely. Based on the advantages of this technique, the paper further investigates their potential applications. The system scans the zebra fish which plays an important role in regenerative medicine with cardiac regeneration then the nano-particles are injected in zebra-fish, which can efficiently enhance the contrast of tissue signal to observe the heart of zebra-fish easily. The heart model of the zebra-fish is similar to the one of human so that cardiac function of zebrafish has potentially become an effective tool for the assessment of human cardiovascular regeneration. A high-resolution animal imaging modality is needed for observing the cardiac function of zebra-fish. According to experiment results, there are 15 dB SNR improvement and 1-2 mm penetration depth improvement by chirp-coded excitation with nano particle. It is suitable for ultrasound bio-microscopy applications.

Biography :

Email: jian0218@gmail.com