Journal of Vaccines & Vaccination

Characterization of different antigens in Salmonella abortusovis for developing a vaccine

4^th International Conference on Vaccines & Vaccination

September 24-26, 2014 Valencia Convention Centre, Spain

Daniela Chessa

Accepted Abstracts: J Vaccines Vaccin

Abstract:

T he majority of the more than 2, 500 known Salmonella serovars cause gastroenteritis in humans, a localized infection characterized by acute intestinal inflammation, diarrhea and fever. Bacterial invasion and survival in host cells in the intestine lead to stimulation of the innate immune system, which results in the massive intestinal inflammatory response that characterizes Salmonella -induced gastroenteritis. Some Salmonella serovars are host restricted and cause systemic infections that differ dramatically in their clinical presentation from gastroenteritis. S. abortusovis is a sheep-adapted pathogen, which does not infect humans. Translocation of bacteria from the intestinal lumen into the lamina propria is detected by the immune system through patter-recognition receptors including TLRs that are able to recognize microbe associated molecular patterns (MAMPs). Lipopolysaccharide, a conserved MAMPs present in the outer membrane of Gram-negative bacteria, is a potent agonist of the TLR4-MD-2-CD14 receptor complex and bacterial flagellin is a MAMP recognized by TLR5. Limited information is available about the immune response of sheep to S. abortusovis and the interactions of this molecular and the TLRs specific. The goal of our study is to characterize virulence mechanisms of S. abortusovis and with this information the development of novel strategies for treatment of infection like a vaccine

Biography :

Daniela Chessa has completed her PhD in the University of Pisa in 2005 in Microbiology and Genetics. Her Doctorate research was on the effects of the expression of a capsule in Salmonella Typhi. In 2005-2009, she was working like a Post doctoral position with Prof. Andreas J. Baumler, California. She studied the effects of the fimbrial in Salmonella Typhimurium and Salmonella Typhi with experiments in vitro and in vivo. Now she is working at the Molecular Biology Lab with Prof. Salvatore Rubino, Italy