Brain Disorders & Therapy

Changes in neuroinflammatory factors in prefrontal cortex in priming-induced methamphetamine reinstatement in REM sleep deprived rats

6^th International Conference on Brain Disorders and Therapeutics

September 13-15, 2018 | Copenhagen, Denmark

Saeideh Karimi Haghighi, Leila Dargahi and Abbas Haghparast

Shahid Beheshti University of Medical Sciences, Iran

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Methamphetamine (METH) is an addictive psychostimulant that is associated with damage to regions of the brain that regulate cognitive function like prefrontal cortex (PFC). Evidence has shown that inflammatory factors play an important role in drug-rewarded behaviour. This shows there is a synergism between CNS and central proinflammatory signaling underlying the rewarding effects of psychostimulant. Cannabidiol (CBD) is a non-psychotomimetic compound of the herb Cannabis sativa that has anti-inflammatory effect. Our previous study showed that CBD not only prevented reinstatement of METH but also inhibited reinstatement in rapid eye movement (REM) sleep deprived (RSD) rats. Based on these data, the present study was undertaken to assess the changes in gene expression of cytokines include IL-1?, 6, 10 and TNF-? in the effect of CBD on METH-induced reinstatement in RSD rats by real time-PCR. Our data indicated that METH-induced reinstatement in the normal and RSD rats augmented TNF-?, IL-1? and 10 the expression in the PFC. Moreover, our results showed CBD relieved the expression level of IL-6, 10 and 1? in the PFC in normal but not in RSD rats. Taken together, cytokines include IL-1-?, 10 and TNF-? are involved in the reward circuit is impacted by METH exposure. Moreover, CBD may effect on METH-induced reinstatement via decrease in cytokines. Previous studies demonstrated that cytokines could change in neurotransmitters that are involved in the reinstatement like dopamine and glutamate. Therefore, it was suggested cytokines may via effect on neurochemistry of the brain regulate reward circuit.

Biography :

E-mail: skarimi43@yahoo.com