Journal of Vaccines & Vaccination

â??BUL BIO-NCIPDâ? company with traditions in vaccine production and with a look ahead to future

6^th Euro Global Summit and Expo on Vaccines & Vaccination

August 17-19, 2015 Birmingham, UK

Daniela Pencheva

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

The traditions of “Bul Bio-NCIPD” in the production of established vaccines as BCG, TETATOX, DIFTET, DIFTETKOK
and TETADIF are longstanding. Produced is also PPD Tuberculin, ready to use for Mantoux’s intradermal test to assist
in clinical diagnosis of tuberculosis. The improved from the WHO, vaccines give the ability for its distribution worldwide.
Efforts are oriented to maintaining the quality of the approved production by meeting the requirements of GMP and ISO 9001:
2008 and at the same time to develop innovations focused on reducing side effects if possible by keeping the strength of the
immune response to vaccination. Studied parallel were the possibilities for obtaining ghost vaccines using nanotechnology
and obtaining transgenic bacteria with included therein viral genome. The scientific challenge in such developments is big
and requires coordination of efforts of various specialists. Development of a vaccine for veterinary use of recombinant “ghost”
cell carriers of bacterial and viral genome against causes of enteric disease is the basis of a draft proposal with great potential
awaiting development and implementation. At first the minimal bactericidal concentration of PVA / AgNps was defined for
each of the tested 4 Salmonella strains - two strains S. enteritidis, S. newport Puerto Rico and S. typhymurium. Rabbits were
immunized with “ghost” Salmonella antigens. The existence of cross-reactive antigens was determined in the obtained rabbit
sera. The joint O and/or H-antigens in some strains allow selection of smaller number of serotypes that will have extensive
protective effect when they will be used in a “ghost” vaccine.

Biography :

Daniela Pencheva graduated with Master’s degree from the Biological Faculty of Sofia University St. Kliment Ohridski, Bulgaria. She completed Post-graduation
in Microbiology at the “Medical University”, Sofia, Bulgaria. In 2012, she defended PhD degree in “NCIPD”, Sofia, Bulgaria. She is Head of laboratory in QC
Department in “Bul Bio - NCIPD” Ltd. Sofia, Bulgaria. Until now she has many published papers in reputed journals and many poster presentations and proceedings
in Bulgarian and International Congresses and Conferences. She participates in a training process and is Research Consultant of students and young scientists
interested in microbiology and biomedicine.