Brain Disorders & Therapy

Brain Fog and Inflammation in Autism and Alzheimerâ??sDisease-Benefit of Luteolin

International Conference on Brain Disorders & Therapeutics

August 24-26, 2015 London, UK

Theoharis C. Theoharides

Tufts University School of Medicine, USA

Posters-Accepted Abstracts: Brain Disord Ther

Abstract:

Brain fogis defined by reduced cognition, concentration and short-term memory found in patients with autism spectrum disorders (ASDs), chronic fatigue syndrome, fibromyalgia, mastocytosis and �??minimal cognitive impairment,�?� an early presentation of Alzheimer�??s disease. Brain fog may be due to inflammatory cytokines and histamine released from mast cells, which then activate microglia, leading to focal brain inflammation. The flavone luteolin has anti-oxidant, anti-inflammatory, neuroprotective and memory enhancing properties. A luteolin formulation in olive fruit extract improved attention in children with ASDs and brain fog in mastocytosis patients. We showed that some methylated luteolin analogues are more potent and also possess brain-derived neurotrophic factor (BDNF) activity. Liposomal preparations of these flavones could be formulated for intranasal administration that would permit targeted delivery to microglia through the cribriform plexus for the treatment of brain fog in neuropsychiatric disorders (US Patents No. 7,906,153; 8,268,365; 13/009.282).

Biography :

Email: theoharis.Theoharides@tufts.edu