Oral Health and Dental Management

Biological impact of Curcumin on tongue ulcer healing in induced diabetic rats

18^th International Conference on Oral Health & Maxillofacial Surgery

December 05-06, 2016 Madrid, Spain

Menatalla M. Elhindawy

Masnoura University, Egypt

Scientific Tracks Abstracts: Oral Health Dent Manag

Abstract:

Curcumin is a popular traditional medicine was first used in Indian and traditional Chinese medicine; it has a wide range of beneficial properties, including anti-inflammatory, antioxidant, chemo-preventive and chemotherapeutic activity. It can modulate growth factors and their signaling pathways; trasnforming growth facotr β1 (TGF-β1), platelet-derived growth factor, insulin-like growth factor and colony-stimulating factors.The presence of TGF- β in the granulation tissue is of a great importance for efficient healing, since it was shown to stimulate angiogenesis, fibroblast proliferation, myofibroblast differentiation, and matrix deposition. Growth factors levels are affected in diabetes meletus; TGF- β levels within the wound fluid from diabetic rats were diminished and normal elevation of TGF- β in acute wound was absent in diabetic patients. oral administration curcumin increase the endogenous biosynthesis of TGF-β resulting in increased migration of epithelial cells; which lead to smaller ulcer size in the first 9 days.

Biography :

Menatalla is an assistant professor of oral biology; she has graduated from Mansoura Univesty at 2006 and completed her master at 2010 and PhD from 2015 at the same institute. She has been teaching oral biology and dental anatomy for 10 years for both under and post graduate since she was a domenstator, she is the director of internationl student affair unite.

Email: dr.menatalla@gmail.com