Journal of Nanomedicine & Nanotechnology

Bio-inspired process to yield intelligent scaffolds for tissue engineering and nanomedicine

4^th International Conference on Nanotek & Expo

December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Anna Tampieri, Simone Sprio, Monica Sandri and Silvia Panseri

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The present work illustrates how bio-mineralization, an amazing natural process with which nature has realized and optimized a profuse collection of living organisms endowed with astonishing abilities scan be used to guide efforts for developing biomaterials for bone and osteochondral regeneration. In particular it will be illustrated how the self-assembling and bio-mineralization of natural polymeric fibers can be induced by reproducing the conditions of formation of new bone tissue in mammals, thus obtaining a collagen-based matrix where mineralization with nanoparticles of biomimetic apatite can take place. The reproduction of biomimetic conditions of bone synthesis allows obtaining hybrid constructs where the mineral phase is nucleated upon guidance by the chemical features and physical confinement imposed by the polymeric matrix, so that the mineral phase has physical, chemical and ultra-structural resemblance with mineral bone, thus providing very high osteogenic activity when implanted in vivo. Besides, the possibility to vary the degree of mineralization allows to obtain multilayer graded devices able to regenerate the different districts of the articular region (subchondral bone, mineralized and hyaline cartilage). Finally, pinning on the recent development of intrinsic super paramagnetism exhibited by hydroxyapatite nanopowders upon crystallographic and chemically controlled doping with Fe(II)/Fe(III) ions, it will be illustrated how bio-hybrid bone-like devices with intrinsic magnetic properties can be obtained; such devices can increasingly assist the osteogenic and angiogenic capacity of biologically inspired bone and osteochondral scaffolds, through magnetically-driven release of specific growth factors.

Biography :

Anna Tampieri is senior Researcher at ISTEC-CNR coordinating the research group on Bioceramics and Bio-hybrid Composites. She is the author of more than 180 papers published on international Journals and inventor of 15 international patents. She is the Founder of Biotech Company ?FINCERAMICA?. She is the Coordinator of several European projects and national projects belonging to Nanotechnologies and Nanomaterials theme. She is also the member of the Nanomedicine European platform and senior affiliated member of Methodist Hospital Research Institute - Houston (Texas - USA).