Pharmaceutica Analytica Acta

Biochemical studies on the effect of medicinal plant Annona Cherimola species in cholesterol induced rats

2^nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

06-08 June 2011, Las Vegas, USA

K.S.Chandana, Chakrapani.P, Venkatesh.K, Amareshwari.P, Prem Kumar, Saraswathi and Anupalli Roja Rani

Posters: PAA

Abstract:

Annonas are economically important in many countries of Africa and Asia as well as in South, North and Central America. In general, the annonas are shrubs or small trees, with height from 5.0 to 7.5 m; they are erect or somewhat spreading and possess grey-brown bark, oft en rough and corrugated. Th ey also serve as sources of medicinal and industrial products. Annona fruits provide good carbohydrate nutrition, acting as excellent sources of energy. Th ey are important sources of minerals, such as calcium, phosphorus and potassium. Th ese are important in biological functions, such as helping to protect bones and teeth, providing strong muscles and improving general health. Annona plant parts used in folk medicine contain chemical compounds such as tannins, alkaloids and fl avonoids found in the roots, leaves, bark, fruits and seeds. Acetogenins, for instance, are present in the seeds, roots, bark, stems and fruits of most annona trees, and appear to have great potential in anti-cancer treatments and as anti cholesterol . Cherimoya roots have aporphine alkaloids, which have a relaxant eff ect. Cholesterol is known to involve oxidative stress and changes in lipid metabolism. Cholesterol induced by triton WR 1339 injection at a dose of 0.20 mg/kg. Animals of treated groups were given the dose of 0.50 mg/kg of the extract. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profi les and therefore may play an important role in the anti obesity and hypolipidemic eff ects. Many secondary plant metabolites have been shown to possess antioxidant activities, improving the eff ects of oxidative stress due to cholesterol. Our study has analysed that the antioxidant eff ect of oral administration of methanol extract of Annona cherimola leaf on antioxidant enzymes and lipid peroxidation in blood-Triton WR 1339 induced rat.

Biography :

K.S.Chandana ( M.Tech), doing Project under Dr. Anupalli Roja Rani (Associate Professor), Department of Genetics, Osmania University, Hyderabad-500007, Andhra Pradesh, India.