Journal of Liver

Bilirubin nanoparticles as nanomedicine for liver fibrosis therapy

4^th International Conference on Hepatology

April 27-28, 2017 Dubai, UAE

Poilil Surendran Suchithra, Reju George Thomas, Sejy Lee, Sangyong Jon and Yong Yeon Jeong

Chonnam National University Medical School, Korea
Korea Advanced Institute of Science and Technology, Korea

Posters & Accepted Abstracts: J Liver

Abstract:

Bilirubin is hydrophobic in nature and polyethylene glycol (PEG; molecular weight, 2,000) was covalently attached to this compound via a stable amide bond resulting in PEGylated bilirubin (PEG-BR). PEG-BR is found to have ability to undergo a solubility switch from hydrophobic to hydrophilic in response to intrinsic ROS. PEG-BR is a novel nanovesicle system which is studied for its multi-stimuli-responsive mechanism utilized as ROS/drug-delivery carriers. Advanced liver fibrosis is a condition characterized by ROS stress and metabolical effects in hepatocytes. In our study, we use PEG-BR as a ROS quenching, anti-inflammatory agent which also have ability to load hydrophobic or hydrophilic drug against progression of fibrosis. We have developed liver fibrosis model in C3H/HeN mice by administering thioacetamide and ethanol. PEGBR was injected through intravenous route in 3 dosages for a period of 9 days. Finally, we analyzed hepatic histopathology and biochemical estimation, respectively. We observed a dosage dependent improvement of hepatic fibrosis and biochemical examination (AST/ALT ratio) in the PEG-BR treated group. PEG-BR nanovesicles might be useful in reduction of mice hepatic fibrosis model.

Biography :

Poilil Surendran Suchithra has completed her MSc in Chemistry from Calicut University, India during 2011-2013. At present, she is pursuing her PhD under Prof. Yong Yeon Jeong developing hepatitis mice model therapy using nanoparticle as well as stem cell therapy and conducting pre-clinical testing at Clinical Vaccine R&D Centre of Chonnam National University Hwasun Hospital, South Korea.

Email: 9pssuchithra@gmail.com