Journal of Psychiatry

Bacterial constituents as potential biomarkers for Alzheimer's Disease and mild cognitive impairment patients

4^th Global Congress on Neuroscience Psychiatry and Mental Disorder

November 18-19, 2024 | Paris, France

Andreadou Eleni

Aristotle University of Thessaloniki, Greece

Scientific Tracks Abstracts: J Psychiatry

Abstract:

The association between bacterial infections and Alzheimer’s disease (AD) has been reported many times in the last 30 years. The aim of this study was the investigation of the possible lipopolysaccharides’ (LPS) involvement, bacterial constituents of the outer membrane of Gram-negative bacteria, in AD. LPS levels were determined in cerebrospinal fluid (CSF) and blood serum (BS) of AD and Mild Cognitive Impairment (MCI) patients, compared to neurologically normal individuals, using indirect ELISA. Specifically, LPS levels were measured in CSF of 54 AD and 47 MCI patients, and BS of 18 AD and 26 MCI patients, while 23 and 13 neurologically normal individuals, respectively, were used as a control group. In the same study, the inflammatory biomarkers COX-1 and COX-2 and the established biomarkers of AD in CSF, tau, and Aβ-42, were also estimated, both in CSF and BS. LPS levels in CSF of AD and MCI patients were increased in comparison with healthy individuals. LPS was additionally found to be raised in BS of AD patients according to healthy donors and MCI patients. LPS was also studied with ROC curves to analyze their possible significance as a biomarker in BS and CSF. Based on this analysis LPS in BS could be proposed as a promising biomarker, able to discriminate AD patients from healthy individuals and MCI patients. Furthermore, LPS levels correlate positively with COX-1/2 levels in BS and CSF and in a negative manner with the mental state of participants, both in BS and CSF.

Biography :

Andreadou Eleni obtained a PhD in Biochemistry at the Biochemistry Laboratory of the Chemical Department of Aristotle University of Thessaloniki. She is quite experienced in various research topics including Alzheimer’s disease. She has participated in 5 research programs and she has 11 publications in international journals and 11 participations in conferences. Nowadays she is a postdoctoral researcher in the Biochemistry Lab of the Chemical Department of AUTH in a research funded by the ΕΔΒΜ103 Program (MIS 5047901) co-financed by the European Union (European Social Fund – ESF) and Greek national funds through the Operational Program “Human Resources Development, Education and Lifelong Learning 2014-2020”. Andreadou Eleni obtained a PhD in Biochemistry at the Biochemistry Laboratory of the Chemical Department of Aristotle University of Thessaloniki. She is quite Andreadou Eleni