Gerontology & Geriatric Research

ASTRAGALUS INCREASE TG2576 MICE TO SCAVENGE TOXIC ADDLS AND RESTORE HOMEOSTASIS OF SYNAPSE PREVENTING DEVELOPMENT OF ALZHEIMERâ??S DISEASE

2^nd International Conference on Aging & Gerontology

June 26-27, 2017 San Diego, CA, USA

Yuesong Gong

Nanjing University, China

Posters & Accepted Abstracts: J Gerontol Geriatr Res

Abstract:

Alzheimer�??s disease (AD) is characterized with pathological changes: β-amyloid plaques, phosphorylated tau tangles and synaptic loss. The effective therapeutic is unavailable to prevent AD development. Based on the Chinese Medicine about the principle of �??The full of Inborn Qi makes the Jing and Shen filled the loss of Inborn Qi results into Jing and Shen shorted�?�, in this study, we used Astragalus for Inborn Qi to clean the oligomers of Aβ (ADDLs) and protect synaptic function to prevent AD development at an early stage. The transgenic Tg2576 AD mice at 3 months old were treated with 100mg/Kg extracts of Astragalus each day for 3 months, the multiple methods, including water maze test, immunocytochemistry were used to examine memory change of Tg2576 and the relevant mechanism. The results showed Astragalus can increase space, memory function of Tg2576 mice to decrease the time for finding safe platform to 47% (p<0.01) in the brains of Tg2576 mice to rescue the homeostasis of synapse, compared with these levels in brains of Tg2576 mice without treatment, respectively and Astragalus can increase immunological function and neuronal autophage to clean ADDLs, and increase insulin signal and protect various ATPases to restore synaptic homeostasis, preventing AD development. In addition to AD, these results showed Astragalus could also be used to prevent neurodegenerative diseases such as PD, FTD and DLB diseases, clean misfolding proteins and protect synaptic function at an early stage.