Journal of Bioequivalence & Bioavailability

Application of nanostructured materials and polymer composite modifi ed electrodes for electrochemical determination of drugs and biomolecules

International Conference and Exhibiton on Pharmaceutical Regulatory Affairs

6-7 September 2011 Baltimore, USA

Shen Ming Chen

Scientific Tracks Abstracts: JBB

Abstract:

W e have developed a novel biocomposite material for the electrocatalysis of p-acetamidophenol using Multi-walled carbon nanotubes (MWCNTs) and poly (aniline) and poly (fl avin adenine dinucleotide) copolymer (PANIFAD) at gold electrode and screen printed carbon electrodes (SPCE). Th e developed MWCNTs-PANIFAD biocomposite fi lm for the electrocatalysis combines the advantages of ease of fabrication, high reproducibility and suffi cient long-term stability. In another approach we have fabricated metal hexacyanoferrates- conducting polymer fi lm based sensor for the simultaneous determination of p-acetamidophenol and ascorbic acid. We proposed easy and convenient method for the detection and determination of melamine by employing oxidized polycrystalline gold electrode (poly GE). Th e poly GE successfully detects the melamine signal (0.06-0.85 ppm) in tainted milk powder samples. It also exhibited two well-separated anodic oxid ation peaks for urine and melamine in melamine- spiked human urine samples with high sensitivity. We used simple preanodized SPCE for the electrochemical detection of a hypnotic agent propofol. Th e preanodized SPCE is found to be much eff ective for the detection of propofol in physiological pH conditions. Furthermore, the proposed SPCE overcomes the interference eff ects and eff ectively shows the oxidation peaks for the detection of propofol in urine samples. Nano TiO2 -conducting polymer, poly(3,4- ethylenedioxythiophene) (PEDOT) composite modifi ed electrodes for the detection of Diclofenac which is an essential anti-infl ammatory drug to reduce infl ammation.

Biography :

Dr. Shen-Ming Chen received his Bachelor Degree in Chemistry in 1980 from National Kaohsiung Normal University, Taiwan. He received his Master Degree (1983) and Ph.D. Degree (1991) in Chemistry from National Taiwan University, Taiwan. He is currently a professor at the Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taiwan. His current research interests include electroanalytical chemistry, bioelectrochemistry, fabrication of energy conservation and storage devices and nanomaterial synthesis for electrochemical applications. He has published more than 200 research articles in SCI journals.