Journal of Nutritional Disorders & Therapy

Antioxidant activity of selenium-rich protein in the pearl oyster pinctada martensii on wistar rat cardiomyocytes

Joint Event on Advances in Neonatal and Pediatric Nutrition & 14^th International Congress on Advances in Natural Medicines, Nutraceuticals & Neurocognition

July 19-21, 2018 | London, UK

Lili Ji, Lu Cai, Jianshe Liu, Jian Guo and Wendong Song

Zhejiang Ocean University, China

Scientific Tracks Abstracts: J Nutr Disorders

Abstract:

Selenium is an essential micronutrient, whose main function is as an antioxidant through its incorporation into proteins to alleviate oxidative stress in cells. This study examined the effects of selenium combined with protein through the selenitealgae- oyster pathway in the pearl oyster Pinctada martensii. The study was designed to explore the possible role of selenoprotein against oxidative damage induced by hydrogen peroxide (H2O2) of cardiomyocytes and its potential mechanisms. The results showed that the combination rate between selenium and protein improved significantly via the enrichment effect. Furthermore, selenoprotein can protect cardiomyocytes that are oxidatively injured by H2O2. The beneficial effects of selenoprotein were likely mediated by an inhibition of Malondialdehyde (MDA) and an increase in the activity of Superoxide Dismutase (SOD) and Glutathione peroxidase (GSH-Px), A maintenance of the mitochondrial membrane potential and a reduction of intracellular Ca2+ overload.

Biography :

Lili Ji is currently a doctoral candidate at the College of Environmental and Science Technology of Donghua University. She has published more than 10 papers in reputed journals. Lili Ji has completed her PhD at the College of Environmental and Science Technology of Donghua University. Her research field is high value utilization technology of marine resources. She has published more than 30 papers in reputed journals

E-mail: jll-gb@163.com