Health Care : Current Reviews

Anticancerous efficacy of compound isolated and formulation of drug from the methanolic extract of avicennia marina (leaf) and its gold nanoparticles using docking studies

Joint Webinar: 14^th International Conference on Clinical Case Reports & 6^th International Conference on Pediatrics and Healthcare & 10^th World Summit on Oncology and Cancer Science

November 24, 2022 | Webinar

S Yamini Sudha Lakshmi

University of Madras, India

Scientific Tracks Abstracts: Health Care Curr Rev

Abstract:

Avicennia marina, commonly known as grey mangrove or white mangrove, is a species of mangrove tree classified in the plant family Acanthaceae (formerly in the Verbenaceae or Avicenniaceae). It is a type of mangrove that occurs in the intertidal zones of estuarine areas. Screening was done by carrying out the phytochemical analysis both qualitatively and quantitatively. Qualitative analysis showed the absence of Alkaloids and presence of Flavonoids Tannins, Phenols, Terpenoids, Glycosides, Saponins and Steroids. Three compounds namely Flavonoids Phenols and Terpenoids were identified using TLC with their respective standards. GC-MS profiling of crude methanolic extract of Avicennia marina showed the presence of nine compounds. Docking studies using Proteins related to Breast cancer like, BRCA1 protein, BRCA2 protein, RAD51 and RAD52 proteins: Over expressed in different cancers. Expression measured in conjunction with BRCA1 and 2 expression, PALB2 – Protein that localizes with BRCA2 protein, ABCG2 or BCRP – Breast cancer resistance protein, p53 protein, other common noval proteins associated with its function (elF4B, TPT1, hnRNPH3, SFRS1 etc) were carried out and the score for the best protein was identified. Also proteins related to Liver cancer like p62 – Specific protein related to liver cancer, Proteins associated with liver cancer, NRF2, mTORC1, c-myc and NOS were assessed. The Gold nanoparticles synthesized from the leaf extract of Avicennia marina were characterized using UV-Visible spectroscopy; FTIR, XRD and SEM analysis were performed. DPPH assay and MTT Assay were performed to check the anticancerous activity with the methanolic leaf extract and gold nano particles of Avicennia marina proving its efficacy as one more additional anticancerous drug. Theproperties of the compounds isolated were compared with the standard drug available in the market for formulation with curcumin to prove its efficacy with less side effects. Key Words: Avicennia marina, Gold Nanoparticles, Characterisation, Docking studies and Anticancerous Activity- Formulation of Drug.

Biography :

S Yamini Sudha Lakshmi is an academician with PhD, PGDBI, FBSS, FABMS, CRA and 34 years of rich experience in the academic world (Teaching and Research). Present she is working in the department of medical Biochemistry as Assistant Professor, University of Madras from 2014 onwards till date. Current Research is in Food Formulations, Compound Isolation from plant / microbial sources and their applications in anti- Cancerous activity. Served as HOD in Department of Biochemistry in colleges affiliated to University of Madras from 2002 onwards as well as established Department of Bioinformatics in Vinayaka Mission University. Published about 25 papers. Served as Head of Basic Medical Sciences in Asmara College of Medical Sciences, Eritrea, North east Africa for three years. Visited various countries like Sri Lanka, Dubai, Abu Dhabi, France, Germany, Australia, Hong Kong and Singapore to deliver key note talks in International Conferences. In India, served as keynote speaker, plenary speaker and Chaired various sessions in national and International conferences in various universities in Kerala, Kolkatta, Goa, Chandigarh, Bengalore, Trichy, and other places. Completed two projects and currently having two projects. Organized First ever International Conference in the department of Medical Biochemistry in 2028. One amongst the whole body donor for the usage of student’s fraternity. She was Honoured as the Vice Chancellor of World Tamil University, USA from July 2022 onwards.