Pharmaceutica Analytica Acta

Anticancer Drug Resistance in Yeast Translocants

2^nd International Conference on Pharmaceutics & Novel Drug Delivery Systems

20-22 February 2012 San Francisco Airport Marriott Waterfront, USA

Dmitri V. Nikitin

Accepted Abstracts: Pharm Anal Acta

Abstract:

Novel metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H 2O)2(1) (synthesized via astatic self-assembly process) and Sn(phen)(NO3 )(OH)(H2O) (2), Sn(5-NH2-phen) (OH)(Cl)(H2O) (3), Pb(5-NH2 -phen)(NO3)2(H2 O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The best pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high amounts as well as 1 at its lower ones (â?¤ 4.10 -2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities â?¤ 4.10 -2 mg.