Journal of Liver

Anti HAV and anti HBs status in children with chronic liver disease at a super speciality centre: Need for urgent vaccination

CO-ORGANIZED EVENT: 5^th World Congress on Hepatitis & Liver Diseases & 2^nd International Conference on Pancreatic Cancer & Liver Diseases

August 10-12, 2017 London, UK

Arun Kumar Sharma, Srikant K P, Jagdish Menona and Babu Ram Thapa

Post Graduate Institute of Medical Education and Research, India

Scientific Tracks Abstracts: J Liver

Abstract:

Background: Hepatitis B virus (HBV) infection is a major public health problem in many countries. Besides infection of hepatitis a virus (HAV) in chronic liver disease (CLD) lead to decompensation with frequent hospitalisation. The immune status against HAV and HBV of children with CLD admitted in this hospital is not known whom vaccination can be advised. Aim: The aim is to evaluate anti HBs status and exposure to hepatitis A virus (anti HAV IgG) among children with chronic liver disease attending Gastroenterology Department, Nehru Hospital, PGIMER, Chandigarh. Methods: 182 children (103 males, 79 females) of chronic liver disease admitted between April 2017 to April 2017 were included in the study (exclusion - Chronic HBV and Chronic HCV patients). Clinical features of patients, routine diagnostic investigations including abdominal ultrasound findings were recorded. Two ml of blood was collected from every patient and their serum stored at -20°C. Tests for detection of HBsAg, anti HCV, anti HAV IgG, and anti HBs were uniformly done on all samples by ELISA. Results: Overall 143 children with CLD (78.5%, 143/182) had undetectable level of anti HBs antibody. Among 182 children of CLD, 156 patients (85.7%) were non-reactive for anti HAV IgG by ELISA. All patients were non-reactive for HBsAg and anti-HCV. Conclusion: 78.5% children with chronic liver disease undergoing hospital treatment were susceptible for hepatitis B virus infection. 85.7% of these admitted children were also susceptible for hepatitis A virus infection. These patients needed recommendations for vaccination against HBV and HAV in present scenario.

Biography :

Sharma is a Medical Graduate and did his Post Graduation in Medical Microbiology. He has published more than 35 papers in various journals and presented 40 papers at different national and international conferences. His research works are in the field of Hepatitis A, Hepatitis B,Hepatitis C and Delta virus infections in adults and children. He has also worked in HIV-HCV co-infection among intravenous drug abusers. He has been given several awards at national conferences. His research focus is on changing trends in vaccine preventable disease specially of Hepatitis A and Hepatitis B virus among children,adolescents and adults.Other research interests include prevention,natural history,molecular virology of Hepatitis B and Hepatitis C virus. He has delivered various guest lectures at different national and international forums on viral gastroenteritis,HCV diagnostic dilemma and on Hepatitis A vaccination.