Journal of Bioequivalence & Bioavailability

Anti depressant activity of Aqueous extract of Terminalia chebula fruits in rodents

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

J.R. Raul, P. Mishra, B. Chowdhury and S. K. Bhattamishra

Posters: J Bioequiv Availab

Abstract:

Terminalia chebula is commonly known as Myrobalan (English) belonging to the family Combretacea. It contains tannins, saponins, steroids, terpenoids, carbohydrates, flavonoids. The Anti-depressant activity of the aqueous extract of Terminalia chebula at a dose level of 100, 200 and 400 mg/kg body weight was evaluated in both the methods of Forced swim test and Tail suspension test. Acute administration of aqueous extract of Termenalia chebula at a dose of 400 mg/kg showed significant (P < 0.01) decrease in duration of immobility in both the methods of depression compared to control group. Whereas chronic administration of aqueous extract of Terminalia chebula at all doses (200 and 400 mg/kg) significantly (P < 0.01) decreased the duration of immobility in Forced swim test where as in Tail suspension test only 400 mg/kg showed significant (P < 0.01) decrease in duration of immobility compared to control group. The locomotor activity of the extract at a dose of 400 mg/kg body weight did not show any significant change, which indicates the decrease in duration of immobility is not due to CNS stimulant effect. Therefore the aqueous extract of Terminalia chebula may have potential therapeutic value for management of depressive disorder.