Journal of Pharmacogenomics & Pharmacoproteomics

Alteration of circulating microRNAs to predict lymphoma initiation and progression via a systems biology approach

5^th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics

December 01-02, 2016 Valencia, Spain

Afshin Beheshti

Tufts Medical Center, USA

Posters & Accepted Abstracts: J Pharmacogenomics Pharmacoproteomics

Abstract:

Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age, starting from young adulthood. The molecular etiology of this remains largely unknown. We propose that there are predictable, age-dependent circulating microRNA (miRNA) signatures in the blood that influence NHL initiation and progression. To investigate this we utilized a novel murine model for spontaneous DLBCL initiation at two age groups: 2 and 15 months old. All spontaneous DLBCL mice will start to develop visible tumors starting at 15 months of age. Using systems biology techniques we determined a list of 10 circulating miRNAs present in the blood of DLBCL forming mice that are not present in the wild-type mice starting from 2 months of age. Additionally, this miRNA signature heavily impacts JUN and MYC oncogenic signaling. It was determined that there is a key miRNA signature circulating throughout a host prior to the formation of a tumor. This miRNA signature is further modulated by age and the formation of tumors. Leveraging a novel spontaneous DLBCL murine model, we were able to determine an age-based key functional circulating miRNA signature associated with NHL that occurs in the blood. This age based circulating miRNA signature can be used to predict NHL development at a young age before actual tumor formation. Furthermore, this can potentially be used as a simple biomarker at a young age to predict future lymphoma development and allow for advanced novel therapeutic strategies to prevent lymphomagenesis..

Biography :

Email: ABeheshti@tuftsmedicalcenter.org