Journal of Blood Disorders & Transfusion

Adult acute lymphoblastic leukemia biology: A gate towards cure

4^th International Conference on Blood Malignancies & Treatment

April 18-19, 2016 Dubai, UAE

Ahmed M L Bedewy

Alexandria University, Egypt

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Acute lymphoblastic leukemia (ALL) is a neoplastic disease that results from multistep somatic mutations in a single lymphoid progenitor cell at one of several discrete stages of development. Leukemic cells accumulate relentlessly because of their altered response to growth and death signals. While ALL is mostly curable in children, similar progress in the treatment of ALL in adults has lagged behind with some patients suffer from refractory or recurrent disease and cannot be cured with conventional chemotherapy. The established prognostic factors include tumor burden, immunophenotype, cytogenetic findings, molecular genetics and early minimal residual disease detection. However, the need to improve treatment results drove researchersâ?? efforts to extrapolate more prognosis controlling factors, to unravel new ones and to present novel therapeutic drugs. Recently, understanding of disease biology paved the way towards novel personalized therapeutic approaches.

Biography :

Email: dr_ahmed_bedewy@yahoo.com