Journal of Allergy & Therapy

A stepwise approach in the management of chronic spontaneous urticaria in children

7^th International Conference on Allergy, Asthma and Clinical Immunology

September 14-15, 2016 Amsterdam, Netherlands

Magdeline Lee Xin Hui

KK Womenâ??s and Childrenâ??s Hospital, Singapore

Posters & Accepted Abstracts: J Allergy Ther

Abstract:

Background: There is limited literature in the management of Chronic Urticaria (CU) in children. Treatment algorithms are generally extrapolated from adult studies. Methods: A workgroup comprising of allergists, nurses and pharmacists convened to develop a stepwise treatment algorithm in management of children with CSU. Sequential patients presenting to the Pediatric Allergy Service with CSU were included in this observational, prospective study. Results: 98 patients were recruited from September 2012 to September 2013. Majority were male, Chinese with median age 4 years 7 months. A third of patients with CSU had a family history of AU. 10.2% had previously resolved CSU, 25.5% had associated angioedema and 53.1% had a history of atopy. A total of 96.9% of patients achieved control of symptoms, of which 91.8% achieved control with cetirizine. 50.0% of all the patients were controlled on step 2 or higher. 47.8% of those on step 2 or higher were between 2 to 6 years of age compared to 32.6% and 19.6% who were 6 years and older and lesser than 2 years of age respectively. 80% of those with previously resolved CSU required an increase to step 2 and above to achieve CU control. Conclusion: We propose a weight and age-based titration algorithm for different antihistamines for CSU in children using a stepwise approach to achieve control. This algorithm may improve the management and safety profile for pediatric CSU patients and allow for review in a more systematic manner for physicians dealing with CSU in children.

Biography :

Email: magdelineleexh@gmail.com