Journal of Microbial & Biochemical Technology

A plant-based controlled release hard capsule for treatment of intestinal disease

World Congress and Expo on Applied Microbiology

August 18-20, 2015 Frankfurt, Germany

Wai Wa Tang

The Hong Kong Polytechnic University, China

Posters-Accepted Abstracts: J Microb Biochem Technol

Abstract:

The aim of this work is to develop a hard capsule made from corn zein for targeted drug delivery in treatment of intestinal disease. The physical properties and the in vitro performance of the plasticized and crosslinked zein capsule were investigated. Oleic acid and glycerol were added as plasticizers at different ratios. Optimized plasticizing ratio of zein film was 3:1 oleic acid to glycerol having tensile strength of 10.7±0.4 MPa and elongation of 14.4±2.6%. The water vapor permeability of the films increased with the glycerol content due to its hydroscopic property. 5% citric acid was added as a crosslinking agent to improve the tensile strength of the capsule (28.6±1.8 MPa). The zein capsule was made by conventional dip-coating method. Drug release from the zein capsule during 2-hour incubation in simulated gastric fluid was controlled at 2.6±0.2%. After transferred to simulated intestinal fluid, the release increased gradually and attained 48.7±4.3% at the total of 8-hour incubation time. The excellent flexibility and pH-responsive properties of zein would be beneficial for the delivery of antimicrobial peptide and protein drugs.

Biography :

Wai Wa Tang has completed her undergraduate study of Food Science and is having her MPhil study in The Hong Kong Polytechnic University