Journal of Nanomedicine & Nanotechnology

A comparative evaluation of ethyl cellulose and ethylene vinyl acetate microcapsules of pioglitazone for controlled release

3^rd International Conference on Nanotek & Expo

December 02-04, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Rajesh Konduri

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

The objective of the study is to prepare and compare the ethyl cellulose (EC) and ethylene vinyl acetate copolymer (EVA) microcapsules of pioglitazone for controlled release. Controlled release formulations are needed for pioglitazone because of its short biological half life and for better control of blood glucose levels to prevent hypoglycemia, to enhance clinical efficacy and patient compliance. EC and EVA microcapsules of pioglitazone were prepared by an industrially feasible emulsification ? solvent evaporation method and the microcapsules were evaluated for permeability and drug release characteristics. The microcapsules prepared are spherical, discrete, free flowing and multi nucleate monolithic type. Microencapsulation efficiency was in the range of 96.34-104.30% in the case of EC and 95.0-101.25% in the case of EVA. Pioglitazone release from the microcapsules was slow over 24 hours and depends on core: coat ratio, wall thickness and size of the microcapsules in both the cases. Drug release from the microcapsules was by non-fickian diffusion mechanism. Good linear relationships were observed between wall thickness of the microcapsules and release rate in both the cases. EC microcapsules were more permeable than EVA microcapsules and gave relatively rapid release of pioglitazone. With very low permeability EVA microcapsules were found to be more suitable for the design of controlled release of pioglitazone