Journal of Blood Disorders & Transfusion

β-Thalassemia and coronary artery disease

International Conference on Hematology & Blood Disorders

September 23-25, 2013 DoubleTree by Hilton Hotel Raleigh-Durham Airport at RTP, NC, USA

Mohammad Javad Zibaeenezhad

Scientific Tracks Abstracts: J Blood Disord Transfus

Abstract:

B-thalassemia belongs to the group of hemoglobinopathies, which is the most common monogenic disorder in the world population. Homozygous B-thalassemia is the most sever presentation of the disease. It is estimated that there are at least 20000 individuals with this disorder in Iran; and despite tight screening control, around 400 affected infants are still born annually, which is a major burden on our health system. Minor Beta-thalassemia is a disorder without any special symptoms, which only causes mild anemia. In thalassemia patients, accelerated erythropoiesis and enhanced cholesterol consumption have been suggested as a dominant mechanism of low level of lipoprotein. Hyperlipidemia is a risk factor for cardiovascular disease, although low level of serum lipids can act as a protective factor. Several studies show low incidence of myocardial infarction and coronary artery disease in Beta-thalassemia patients.