Journal of Nutrition & Weight Loss

The Role of Antioxidants in Combating Oxidative Stress and Supporting Healthy Weight

Mark Wright^* Department of Nutritional Sciences, University of Texas, Austin, United States of America
^*Correspondence: Mark Wright, Department of Nutritional Sciences, University of Texas, Austin, United States of America, Email:

Received: 30-Sep-2024, Manuscript No. JNWL-24-28097; Editor assigned: 02-Sep-2024, Pre QC No. JNWL-24-28097 (PQ); Reviewed: 16-Oct-2024, QC No. JNWL-24-28097; Revised: 23-Oct-2024, Manuscript No. JNWL-24-28097 (R); Published: 30-Oct-2024, DOI: 10.35248/2593-9793.24.9.218

Description

The role of antioxidants in weight management has gained attention in recent years due to their potential impact on metabolic processes and their ability to influence factors related to obesity and fat storage. Antioxidants, which are naturally occurring compounds found in various foods, help combat oxidative stress, a condition that occurs when there is an imbalance between free radicals and the body's ability to neutralize them. Chronic oxidative stress is associated with several metabolic disorders, including obesity and may contribute to inflammation, insulin resistance and fat accumulation. This integrative study examines the role of antioxidants in weight management, exploring their potential mechanisms of action, sources and the evidence supporting their efficacy in promoting weight loss and metabolic health [1-3].

One of the primary ways antioxidants are believed to contribute to weight management is through their ability to reduce oxidative stress and inflammation. Oxidative stress can impair metabolic function, leading to the accumulation of fat, especially in visceral adipose tissue, which is associated with increased risk for metabolic diseases such as type 2 diabetes and cardiovascular disease. Inflammation, often a result of oxidative stress, can also interfere with insulin signaling, leading to insulin resistance. Several antioxidants, such as vitamin C, vitamin E, polyphenols and flavonoids, have been shown to reduce oxidative stress and inflammation, potentially mitigating these metabolic disturbances and supporting healthy weight management [4-6].

Vitamin C, a well-known antioxidant, has been widely studied for its potential role in weight management. It plays a key role in collagen synthesis and immune function, but it also helps reduce oxidative stress. Some studies suggest that vitamin C supplementation may improve fat oxidation, which could help individuals burn fat more efficiently during physical activity. Additionally, vitamin C is involved in the synthesis of carnitine, a compound that plays a key role in the transport of fatty acids into mitochondria, where they are burned for energy. Research has shown that individuals with higher vitamin C levels may experience better fat oxidation rates during exercise, suggesting that vitamin C could support fat loss as part of an overall weight management strategy [7-9].

Another antioxidant that has gained attention for its potential role in weight management is vitamin E. As a potent fat-soluble antioxidant, vitamin E helps protect cell membranes from oxidative damage. Some studies have suggested that vitamin E may have anti-inflammatory effects that help reduce adipose tissue inflammation, a common characteristic of obesity. Inflammation within adipose tissue has been linked to impaired fat metabolism and the promotion of fat storage. By mitigating these inflammatory responses, vitamin E may help reduce fat accumulation and promote healthy fat metabolism, thus supporting weight management efforts. However, more research is needed to fully understand the extent of vitamin E's impact on weight loss.

Polyphenols, a diverse group of antioxidants found in fruits, vegetables, tea and other plant-based foods, have also been extensively studied for their potential to support weight loss and metabolic health. Polyphenols, including catechins, resveratrol and curcumin, have been shown to influence several metabolic pathways that regulate fat storage and fat oxidation. For example, catechins, which are abundant in green tea, have been found to increase thermogenesis, the process by which the body generates heat and burns calories. Green tea extract, rich in catechins and caffeine, has been shown to promote fat oxidation and increase energy expenditure, both of which can contribute to weight loss. Resveratrol, found in grapes, red wine and certain berries, has been shown to activate pathways related to fat metabolism, including the activation of sirtuins, a group of proteins that play a role in regulating metabolic processes and energy balance. Some study suggests that resveratrol may help improve insulin sensitivity and reduce inflammation, which can positively impact weight management [10].

References

1. Nam YE, Kim HJ, Kwon O. Acute and prolonged effects of Bacillusamyloliquefaciens GF424-derived SOD on antioxidant defense in healthy individuals challenged with intense aerobic exercise. Free Radic Biol Med. 2024;224:484-493.

   [Crossref] [Google Scholar] [PubMed]

2. Ahmed IA, Zamakshshari NH, Mikail MA, Bello I, Hossain MS. Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care. Fitoterapia. 2024:106282.

   [Crossref] [Google Scholar] [PubMed]

3. Eze FN. Transthyretin amyloidosis: Role of oxidative stress and the beneficial implications of antioxidants and nutraceutical supplementation. Neurochem Int. 2024:105837.

   [Crossref] [Google Scholar] [PubMed]

4. Sekhar RV. GlyNAC Supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, aging hallmarks, metabolic defects, muscle strength, cognitive decline, and body composition: Implications for healthy aging. J Nutr. 2021;151(12):3606-16.

   [Crossref] [Google Scholar] [PubMed]

5. Sobanke AO, Aiyeola A, Okwuonu FI, Nnaemeka WS, Ndubuisi JC, Udeoji FI, et al. Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations. Nutr Metab. 2025;39:200293.

   [Google Scholar]

6. Fu W, Huang Z, Li W, Xu L, Yang M, Ma Y, et al. Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease. Bioact Mater. 2025;46:118-133.

   [Crossref] [Google Scholar] [PubMed]

7. Musa KH, Hamad EM, Elnour AA. Camel milk and oxidative stress: Therapeutic potential against metabolic syndrome diseases. J Agr Food Res. 2025:101682.

   [Google Scholar]

8. Agnihotri P, Malik S, Saquib M, Chakraborty D, Kumar V, Biswas S, et al. Exploring the impact of 2-hydroxyestradiol on heme oxygenase-1 to combat oxidative stress in rheumatoid arthritis. Int J Biol Macromol. 2024;283:137935.

   [Crossref] [Google Scholar] [PubMed]

9. Cai S, Sun Y, Wang Y, Lin Z. Exploring the effect of LncRNA DANCR to regulate the Keap1‐Nrf2/ARE pathway on oxidative stress in rheumatoid arthritis. Immun Inflamm Dis. 2024;12(1):e1163.

   [Crossref] [Google Scholar] [PubMed]

10. Rhodes CH, Hong BV, Tang X, Weng CY, Kang JW, Agus JK, et al. Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men. Nutr Res. 2024;132:125-35.

    [Crossref] [Google Scholar] [PubMed]