Spermine Treated-Adipose Tissue-Derived Multi-Lineage Progenitor Cells Improve Left Ventricular Dysfunction in a Swine Model of Chronic Myocardial Infarction

Hanayuki Okura^1,2,3, Mitsuko Morita¹, Maiko Q Fujita¹, Kyoko Naba¹, Nozomi Hasebe-Takada¹, Akihiro Ichinose⁴ and Akifumi Matsuyama^1,2*

¹Platform of Therapeutics for Rare disease, National Institute of Biomedical Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, ARIC 105, 7-1-3 Doicho, Amagasaki, Hyogo, 660-0083, Japan

²The Center for Medical Engineering and Informatics, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0879, Japan

³Adipo Medical Technology, Inc. 2-8-16, Ajiro-kita, Higashi-Osaka, Osaka, Japan

⁴Department of Plastic Surgery, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan

^*Corresponding Author: