Self-assembly Stability Compromises the Efficacy of Tryptophan-Containing Designed Anti-measles Virus Peptides

Diogo A. Mendonça¹, Tiago N. Figueira¹, Manuel N. Melo², Olivia Harder³, Stefan Niewiesk³, Anne Moscona^4,5,6,7, Matteo Porotto^4,5,8* and Ana Salomé Veiga^1*

¹Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal

²Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2775-412 Oeiras, Portugal

³Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States of America

⁴Department of Pediatrics, Columbia University Medical Center, New York 10032, United States of America

⁵Center for Host-Pathogen Interaction, Columbia University Medical Center, New York 10032, United States of America

⁶Department of Microbiology and Immunology, Columbia University Medical Center, New York 10032, United States of America

⁷Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York 10032, United States of America

⁸Department of Experimental Medicine, University of Study of Campania 'Luigi Vanvitelli', 81100 Caserta, Italy

^*Corresponding Author(s):