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Research Article - (2014) Volume 5, Issue 5

Neutrophilia Due to Silica Nanoparticles Induces Release of Double- Stranded DNA

Kazuma Higashisaka1,2, Akiyoshi Kunieda1, Yuki Iwahara1, Kota Tanaka1, Kazuya Nagano2, Yohei Mukai3, Haruhiko Kamada2,4, Shin-ichi Tsunoda2,4, Yasuo Yoshioka1,2* and Yasuo Tsutsumi1,2*
1Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
2Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8, Saito-Asagi, Ibaraki, Osaka 567-0085, Japan
3Laboratory of Innovative Antibody Engineering and Design, Center for Drug Innovation and Screening, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka 567-0085, Japan
4The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6, Yamadaoka, Suita, Osaka 565-0871, Japan
*Corresponding Author(s):