Molecular Profiling of Human Primary Chondrosarcoma-Derived Spheres Reveals Specific and Target Genes Involved in Multidrug Resistance and Metastasis

Vincenzo Desiderio^1,2#, Francesca Paino^1#, Angela Nebbioso³, Lucia Altucci^3,4, Giuseppe Pirozzi⁵, Federica Papaccio¹, Marcella La Noce¹, Alfredo De Rosa⁶, Gianpaolo Papaccio^1* and Virginia Tirino¹

¹Department of Experimental Medicine Section of Histology, TERM Laboratory, Second University of Naples, Naples, Italy

²Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA

³Department of Biophysics, Biochemistry and General Pathology, Second University of Naples, Naples, Italy

⁴Institute of Genetics and Biophysics (IGB) “Adriano Buzzati Traverso”, Naples, Italy

⁵Department of Experimental Oncology, National Cancer Institute, Naples, Italy

⁶Department of Medicine, Surgery and Dentistry, Second University of Naples, Naples, Italy

^#Contributed equally to this work