CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1α Activation

Shailendra PS¹, McClung JA², Bellner L¹, Cao J^1,3, Waldman M^1,4, Schragenheim J¹, Arad M⁵, Hochhauser E⁴, Falck JR⁶, Weingarten JA^7,8, Peterson SJ^7,8 and Abraham NG^2,9*

¹omi_departments of Pharmacology and Medicine, New York Medical College, Valhalla, New York, USA

²omi_departments of Medicine, New York Medical College, Valhalla, New York, USA

³Chinese PLA General Hospital, Beijing 100853, China

⁴Cardiac Research Laboratory, Felsenstein Medical Research Institute and Sackler School of Medicine, Tel Aviv University, Israel

⁵Leviev Heart Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel

⁶Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA

⁷Weill Cornell Medicine, New York, USA

⁸New York Presbyterian Brooklyn Methodist Hospital, New York, USA

⁹Joan Edward School of Medicine, West Virginia, USA