Comparative Bioavailability and Pharmacodynamic Aspects of Cyclobenzaprine and Caffeine in Healthy Subjects and the Effect on Drowsiness Intensity

Ronilson A. Moreno^1,2, Carlos Eduardo Sverdloff^1,2, Rogério A. Oliveira², Sandro Evandir Oliveira², Diego Carter Borges³, Maristela H. Andraus⁴, Myriam C. Salvadori⁴ and Ney Carter Borges^2,5*

¹Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas – UNICAMP, PB 6111, 13083-970, Campinas, SP, Tel: (0055-19) 3251-9535; Fax: (0055-19) 3289-2968, Brazil

²Synchrophar Assessoria e Desenvolvimento de Projetos Clínicos S/S Ltda: 24, Cesar Bierrenbach st, Campinas, SP, 13015-025, Fax: (19) 3234-2834; E-mail: synchrophar@synchrophar.com, Brazil

³Faculty of Medicine: 250, Francisco Telles st, Jundiai, SP, 13202-550, Tel: (0055-11 4587 1095; Fax: (0055-11) 4587 1095, Brazil

⁴Chrom Analysis- MCM Análises Laboratoriais SA, São Paulo-SP, 05019-000, Tel: +5511 3868-3044; Fax: +5511 3868-4044; E-mail: chromanalysis@uol.com.br, Brazil

⁵Department of Clinical Medicine, Faculty of Medical Sciences, State University of Campinas – UNICAMP, 13083-970, Campinas, SP, Tel: (0055-19) 3521-7098, Brazil