Journal of Bioequivalence & Bioavailability

Bioavailability of Salmeterol Xinafoate in the Perception of Asthma

Piere Bauman^* Department of Pharmacy, University of Neuchatel, Neuchatel, Switzerland
^*Correspondence: Piere Bauman, Department of Pharmacy, University of Neuchatel, Neuchatel, Switzerland, Email:

Received: 23-Mar-2022, Manuscript No. JBB-22-16650; Editor assigned: 28-Mar-2022, Pre QC No. JBB-22-16650 (PQ); Reviewed: 11-Apr-2022, QC No. JBB-22-16650; Revised: 18-Apr-2022, Manuscript No. JBB-22-16650 (R); Published: 25-Apr-2022, DOI: 10.35248/0975-0851.22.14.465

About the Study

Salmeterol xinafoate was created as a powerful β2-adrenoceptor aganist with the pharmacological profile of a long-acting bronchodilator. Asthma and chronic obstructive pulmonary disease are treated with salmeterol xinafoate as a Long-Acting Beta Adrenoreceptor Agonist (LABA). Salmeterol, like other β2- agonists, works by activating β2-adrenergic receptors in the airway smooth muscle to relax it. This raises the intracellular messenger cyclic AMP, which is important for smooth muscle tone regulation. As a result, activation of the β2-adrenergic receptor causes bronchodilation. Muscarinic antagonists also help with bronchodilation, but they do so by competing for muscarinic receptors with acetylcholine. Salmeterol xinafoate, a LABA with 12-hour duration of action, improved bronchodilator efficacy and patient outcomes in asthma patients as compared to short-actingagonists, which have a 4–6-hour duration of action. Salmeterol is commonly used in combination with an Inhaled Corticosteroid (ICS), such as fluticasone, for severe persistent asthma after previous therapy with a SABA, such as salbutamol. The combination of a LABA and an ICS has been proven to be more effective than either component alone, a greater dose of ICS alone, or a combination of ICS and a leukotriene antagonist or theophylline.

Salmeterol is a beta-2 agonist, which means it can be inhaled. Beta-2 receptors in the bronchial musculature are stimulated by these medications. This relaxes them and prevents the start and severity of asthma symptoms. They work by increasing the concentration of cAMP through the enzyme adenyl cyclase (Cyclic adenosine monophosphate). Smooth muscle tone is reduced by cyclic AMP. This medication is 10,000 times more fat soluble than albuterol, a short-acting beta-2 agonist. Salmeterol dissolves in the lipid bilayer of the cell membrane, unlike albuterol, and its slow dissociation from the cell membrane supplies beta-2 adrenoceptors with a sustained supply of agonist. Salmeterol differs from salbutamol and other Short-Acting Beta Adrenoreceptor agonists (SABAs) primarily in its duration of action. In compared to salbutamol, which lasts roughly 4–6 hours, salmeterol lasts about 12 hours. Inhaled salmeterol reduces the number and severity of asthma attacks when administered as directed every day. Formoterol has been shown to have a faster beginning of effect than salmeterol due to its reduced lipophilicity. It has also been shown to be more potent, with a 12 g dose of formoterol being similar to a 50 g dose of salmeterol.

The purpose of product bioavailability is to control and prevent asthma or persistent lung disease symptoms (wheezing and shortness of breath) (Chronic Obstructive Pulmonary Disease- COPD, which includes chronic bronchitis and emphysema). Fluticasone belongs to the corticosteroid class of medicines. It helps by alleviating airway irritation and edoema. Salmeterol belongs to the long-acting beta agonist’s class of medicines. It works by relaxing the muscles surrounding person airways, allowing person to breathe more easily. Controlling the symptoms of breathing issues can help person get back to work or school faster. Long-acting beta agonists (such as salmeterol) may raise the risk of significant (often deadly) asthma-related respiratory issues when administered alone. However, this product's combination of inhaled corticosteroid and long-acting beta agonists does not increase the risk of significant asthmarelated breathing issues. This product should be used for asthma therapy when breathing issues are not effectively managed with a single asthma drug (such as an inhaled corticosteroid) or if person symptoms require combination treatment. It is critical to learn how to utilize this drug properly before using it. To be successful, this drug must be used on a daily basis. It does not act immediately and should not be used to treat asthma attacks that occur suddenly.