A Novel ASK Inhibitor AGI-1067 Inhibits TLR-4-Mediated Activation of ASK1 by Preventing Dissociation of Thioredoxin from ASK1

Li Y¹, Zheng S², Long L², Jenny Zhou H^2,3, Ji W² and Min W^2,3*

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

²The Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

³Interdepartmental Program in Vascular Biology and Therapeutics, Dept. of Pathology, Yale University School of Medicine, New Haven, CT, USA