Modern Chemistry & Applications

Peter M Gannett

Peter M Gannett
Professor, Department of Basic Pharmaceutical Sciences
West Virginia University, USA

Biography

Dr. Gannett received his PhD from the University of Wisconsin-Madison in physical organic chemistry. He has studied the conformation of DNA and proteins for over 25 years. He is a R.C. Byrd distinguished professor of medicinal chemistry in the Basic Pharmaceutical Sciences department. His major areas of interest include chemical carcinogenesis, the effect of DNA adducts on conformation and biological activity, and the mechanism of P450 mediated metabolism. In the area of chemical carcinogenesis, Dr. Gannett’s lab is determining the conformational effects of C8-arylguanine adducts that are biologically derived from carcinogenic arylhydrazines and organic synthesis, oligonucleotide synthesis, circular dichroism, NMR, and computational methods. His research in the area of P450 metabolizing proteins is with respect to electron transfer.To this end a variety of tools and techniques includingHPLC/mass spectrometry, surface plasmon resonance (SPR), electrochemistry, nanotechnology techniques and an interdisciplinary approach.

Research Interest

• Metabolism of hydrazines
• DNA – Structure and comformation
• Z-DNA Binding Proteins
• NMR of oligonucleotides and oligonucleotide/protein complexes
• Cytochrome P450 – Drug Design and Electron Transfer
• Molecular modeling – Molecular mechanics, dynamics, QSAR, Docking/High     throughput screening
• Nanotechnology especially the Materials Science-Biology interface (nanobioscience)
• Reactive oxygen species (ROS)
• Electron Paramagnetic Resonance
• Organic Synthesis – especially of nucleosides and phosphoramidites