Journal of Pharmacogenomics & Pharmacoproteomics

Liu Jiang

Liu Jiang
Associate Professor, Department of Pharmacology, Physiology and Toxicology
Marshall University, USA

Biography

Liu Jiang is currently affiliated to Marshall University and University of Toledo College of Medicine, USA, continuing research in the oxidative stress and Na/K-ATPase signaling transduction in renal sodium handling, salt-sensitive hypertension as well as renal/cardiac fibrosis and organ remodeling.During my research career, through collaboration with Drs. Joseph I. Shapiro and Zijian Xie and other investigators, we demonstrated that cardiotonic steroids- and ROS-mediated Na/K-ATPase signaling is involved in renal sodium handling, and the relevance of the signaling functions of Na/K-ATPase to the pathophysiology of renal and cardiovascular diseases and salt sensitivity. Recently, we demonstrated that cardiotonic steroids signaling through the Na/K-ATPase, generated ROS which is essential for the overall signal transduction.

Research Interest

My research interest is the roles of endogenous cardiotonic steroids, oxidative stress and Na/K-ATPase signaling transduction in renal sodium handling, salt-sensitive hypertension as well as renal/cardiac fibrosis and organ remodeling. During my research career, through collaboration with Drs. Joseph I. Shapiro and Zijian Xie and other investigators, we demonstrated that cardiotonic steroids- and ROS-mediated Na/K-ATPase signaling is involved in renal sodium handling, and the relevance of the signaling functions of Na/K-ATPase to the pathophysiology of renal and cardiovascular diseases and salt sensitivity. Recently, we demonstrated that cardiotonic steroids signaling through the Na/K-ATPase, generated ROS which is essential for the overall signal transduction. In particular, we identified the link of cardiotonic steroids mediated changes in renal salt handling with endocytosis of Na/K-ATPase which together with the ROS signaling forms the platform for a novel mechanism and potential drug and nutrient target.