Bioenergetics: Open Access

Guoli Dai

Guoli Dai
Assistant Professor, Department of Biology
Indiana University-Purdue University Indianapolis, USA

Biography

"Biography: Ph.D., Molecular and Cellular Biology, Jilin University, P.R. China, 1990. M.S., Biology, Changchun Veterinary University, P.R. China, 1987. D.V.M., Changchun Veterinary University, P.R. China, 1984. Current Position: Assistant Professor Department of Biology Center for Regenerative Biology and Medicine Indiana University-Purdue University Indianapolis Areas of Expertise: Reproductive endocrinology, maternal organ adaptations to pregnancy, liver injury and regeneration, and biology of liver stem/progenitor cells. "

Research Interest

My laboratory investigates the molecular mechanisms regulating hepatocyte proliferation and liver growth in both physiological and pathological conditions. The maternal liver adapts to pregnancy by marked growth manifested by hepatocyte proliferation and liver size increase. We are particularly interested in revealing the roles of placental hormones in mediating maternal hepatic adaptations to pregnancy. In response to acute or chronic liver injuries, the liver regenerates, repairing damaged tissue and restoring original structures and functions. The hepatic regenerative response is a phenomenon of compensatory growth of injured liver. We are investigating the functions of transcription factors in regulating hepatocyte proliferation and hepatic stem/progenitor cell activity during liver regeneration. Our goal is to develop a clinical strategy to rescue injured livers by targeting liver repair.