Tropical Medicine & Surgery

Charles J. Malemud

Charles J. Malemud
Professor, Division of Rheumatic Diseases
State University of New York, USA

Biography

Charles J. Malemud received the Ph.D. from George Washington University in 1973 and completed postdoctoral studies at the State University of New York at Stony Brook in 1977. Since 1977, Dr. Malemud has been a member of the faculty at Case Western Reserve University School of Medicine where he is presently Professor of Medicine & Anatomy in the Division of Rheumatic Diseases and Senior Investigator in the Arthritis Research Laboratory. He has published more than 190 peer-reviewed papers, reviews and book chapters primarily in the fields of chondrocyte biology, extracellular matrix and signal transduction pathways. Professor Malemud is an ad hoc reviewer for the National Institute of Arthritis, Musculoskeletal and Skin Diseases. He on the editorial board of several rheumatology, immunology and musculoskeletal journals and is Editor-in-Chief of the Journal of Clinical & Cellular Immunology.

Research Interest

Charles J. Malemud, Ph.D. is the senior investigator in the Arthritis Research Laboratory (ARL) at Case Western Reserve University School of Medicine. Basic research in the ARL is primarily focused on defining how human chondrocyte gene expression is regulated by pro-inflammatory cytokine activation of the Janus Kinase/Signal Transducers and Activators of Transcription, Stress-Activated/Mitogen-Activated Protein Kinase and Phosphatidylinositide-3-Kinase/AKT pathways. We are determining the extent to which these signal transduction pathways regulate transcription factor activity required for induction of apoptosis and matrix metalloproteinase gene expression, both of which are relevant to the pathogenesis and progression of inflammatory arthritis.