Journal of Nanomedicine & Nanotechnology

Zhiguo Zhou

Publications

• Research Article
  Effects of Novel Nanomaterials on Allergic Mediator Release from Human Mast Cells and Basophils through Non-Ige Mediated Pathways
  Author(s): Anthony Dellinger, D. Bradford Brooks, Beverly Plunkett, Becky M. Vonakis, Marinella Sandros, Zhiguo Zhou and Christopher L. KepleyAnthony Dellinger, D. Bradford Brooks, Beverly Plunkett, Becky M. Vonakis, Marinella Sandros, Zhiguo Zhou and Christopher L. Kepley
  
  Mast cells (MC) and peripheral blood basophils (PBB) are well known for their role in the allergic response mediated through high affinity IgE receptors (FcεRI). However, these cells can also be stimulated by other non-allergic secretagogues to release their inflammatory mediators. Certain fullerene derivatives (FD) have already been shown to stabilize FcεRI-mediated MC/PBB responses, but it is not know if they also stabilize these cells through non-IgEmediated mechanisms. A panel of FD was synthesized and tested for their ability to inhibit non-FcεRI mediated release from human MC and PBB. It was found that specifically engineered FD could significantly inhibit calcium ionophore, compound 48/80, somatostatin, and poly L-lysine induced MC degranulation and cytokine production, as well as blunt degranulation and cytokine production from N-formyl-methionine-leuci.. View More»
  DOI: 10.4172/2157-7439.1000153

  Abstract PDF