Journal of Microbial & Biochemical Technology

Zheng Chen

Publications

• Research Article
  Inactivation and Disinfection of Zika Virus on a Nonporous Surface
  Author(s): Cameron Wilde, Zheng Chen, Tanya Kapes, Cory Chiossone, Salimatu Lukula, Donna Suchmann, Raymond Nims and S Steve ZhouCameron Wilde, Zheng Chen, Tanya Kapes, Cory Chiossone, Salimatu Lukula, Donna Suchmann, Raymond Nims and S Steve Zhou
  
  The zika virus (ZIKV), an emergent arbovirus within the flavivirus family, is of public health concern due to the lack of a vaccine and possibility of teratogenic effects in infected pregnant women. The flaviviruses are enveloped, and it might be expected that inactivation methods for enveloped viruses in general might be effective for ZIKV. We have investigated a number of physical and chemical inactivation approaches using both low protein (5% serum) and 90% blood organic loads present during drying of virus onto carriers. ZIKV in 90% blood displayed ~0.06 log10 per hour inactivation over 8 h, while virus in 5% serum was inactivated at a much higher rate (~0.5 log10 per h). ZIKV was susceptible to dry heat treatment (56°C–60°C) when dried in 5% serum, but less so when dried in 90% blood. A quaternary ammonium/alcohol-based product and 70% isopropyl alcohol caused compl.. View More»
  DOI: 10.4172/1948-5948.1000319

  Abstract PDF