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Zhang Z. Gang
Zhang Z. Gang
Tanzania
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Research Article
Targeting Triple Negative Breast Cancer with a Small-sized Paramagnetic Nanoparticle
Author(s): Li Zhang, Nadimpalli RS Varma, Zhang Z. Gang, James R. Ewing, Ali S Arbab and Meser M AliLi Zhang, Nadimpalli RS Varma, Zhang Z. Gang, James R. Ewing, Ali S Arbab and Meser M Ali
There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). We developed a small-sized dendrimer-based nanoparticle containing a clinical relevant MRI contrast agent, GdDOTA and a NIR fluorescent dye, DL680. Systemic delivery of dual-modal nanoparticles led to accumulation of the agents in a flank mouse model of TNBC that were detected by both optical and MR imaging. In-vivo fluorescence images, as well as ex-vivo fluorescence images of individual organs, demonstrated that nanoparticles accumulated into tumor selectively. A dual modal strategy resulted in a selective delivery of a small-sized (GdDOTA)42-G4-DL680 dendrimeric agent to TNBC tumors, avoiding other major organs. .. View More»
DOI: 10.4172/2157-7439.1000404