Journal of Nanomedicine & Nanotechnology

Yuvienco C

Publications

• Research Article
  Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery
  Author(s): Min Dai, Frezzo JA, Sharma E, Chen R, Singh N, Yuvienco C, Caglar E, Xiao S, Saxena A and Montclare JKMin Dai, Frezzo JA, Sharma E, Chen R, Singh N, Yuvienco C, Caglar E, Xiao S, Saxena A and Montclare JK
  
  We have fabricated protein polymer-gold nanoparticle (P-GNP) nanocomposites that exhibit enhanced binding and delivery properties of the small hydrophobic molecule drug, curcumin, to the model breast cancer cell line, MCF-7. These hybrid biomaterials are constructed via in situ GNP templated-synthesis with genetically engineered histidine tags. The P-GNP nanocomposites exhibit enhanced small molecule loading, sustained release and increased uptake by MCF-7 cells. When compared to the proteins polymers alone, the P-GNPs demonstrated a greater than 7-fold increase in curcumin binding, a nearly 50% slower release profile and more than 2-fold increase in cellular uptake of curcumin. These results suggest that P-GNP nanocomposites serve as promising candidates for drug delivery vehicles .. View More»
  DOI: 10.4172/2157-7439.1000356

  Abstract PDF