Journal of Allergy & Therapy

Yujin Sutoh

Publications

• Research Article
  Solute Carrier Family 6 Member 12 Gene Polymorphisms in Japanese Patients with Aspirin-Exacerbated Respiratory Disease
  Author(s): Motohiro Kurosawa, Yujin Sutoh, Tatsuo Yukawa, Soichiro Hozawa and Eijin Sutoh Motohiro Kurosawa, Yujin Sutoh, Tatsuo Yukawa, Soichiro Hozawa and Eijin Sutoh
  
  Background: Betaine/gamma-aminobutyric acid (GABA) signaling pathway in the airway epithelium has been revealed to play a critical role in bronchial asthma. To elucidate any genetic influence of the GABAergic in aspirinexacerbated respiratory disease (AERD), we investigated the association of solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12 (SLC6A12) gene in Japanese patients with AERD. Methods: DNA specimens were obtained from 103 AERD patients, 300 patients with aspirin-tolerant asthma (ATA) and 100 normal controls. Allelic discrimination assay for two single nucleotides polymorphisms in SLC6A12 gene (rs499368 and rs557881) was carried out. Results: The minor allele frequencies in SLC6A12 intron 2 A>T genotype (rs49936) were higher in AERD patients than in normal controls, and that in SLC6A12 exon 4 T>C genotype (rs557881) were higher in AERD pati.. View More»
  DOI: 10.4172/2155-6121.1000220

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