Journal of Nanomedicine & Nanotechnology

Yu-Chie Chen

Publications

• Research Article
  Using Glucose-bound Fe3O4 Magnetic Nanoparticles as Photothermal Agents for Targeted Hyperthermia of Cancer Cells
  Author(s): Ching-Yi Wu, Chia-Hua Lin and Yu-Chie Chen Ching-Yi Wu, Chia-Hua Lin and Yu-Chie Chen
  
  Cancer remains as a top leading cause of death for decades. Thus, efforts have been devoted in exploring effective therapeutic methods of treating patients suffering from the disease. In this study, we proposed a targeted hyperthermia approach that can be used to inhibit the growth of cancer cells by combining functional iron oxide (Fe3O4) magnetic nanoparticles (MNPs) with illumination of near-infrared (NIR) light. Cancer cells express more glucose receptors on their cell membrane than normal cells. Furthermore, Fe3O4 MNPs are known to possess photothermal features. An aqueous solution containing the generated MNPs (1 μg μL-1, 100 μL) can be heated from 37°C to over 50°C under irradiation of a NIR laser (808 nm) within 3 min. We immobilized glucose-6-phosphate on the surface of Fe3O4 MNPs (Glu-Fe3O4 MNPs) through phosphate-Fe(III) chelation and used the generated glu.. View More»
  DOI: 10.4172/2157-7439.1000264

  Abstract PDF