Journal of Bioequivalence & Bioavailability

Young Ee Kwon

Publications

• Editorial
  Pharmacokinetic Profiles of Two Branded Formulations of Piroxicam 20mg in Healthy Korean Volunteers by a Rapid Isocratic HPLC Method
  Author(s): Hyun Ho Song, Kwang Sik Choi, Chan-Wha Kim and Young Ee KwonHyun Ho Song, Kwang Sik Choi, Chan-Wha Kim and Young Ee Kwon
  
  The aim of this study was to develop and validate f or determination of piroxicam in human plasma by new rapid HPLC method and to compare the relative bioavailability of two branded formulations of piro xicam in healthy Korean volunteers. The analysis running time of piroxicam was just 2 minutes using C 18 column (100 x 4.6 mm, 5 μ m) with variable wavelength detector (at 355 nm). This HPLC method was validated by examining the precision and accuracy for inter- and intra-day analy- sis. A randomized, open-label, single dose, 2-perio d cross- over method was performed in 28 subjects. For analy sis of pharmacokinetic properties, the blood samples we re drawn at 0, 1, 2, 3, 4, 5, 6, 12, 24, 48, 96 and 16 8 hours after dosing. The standard curve was linear (R 2 = 0.9999) over the concentration range of 0.1 - 6 μ g/mL. The rela- tive standard deviation (R.S.D.) and accuracy were .. View More»
  DOI: 10.4172/jbb.1000011

  Abstract PDF