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Yoshiyasu Kigawa
Yoshiyasu Kigawa
Japan
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Research Article
Retrospective Study of Trazodone Monotherapy Compared with Ramelteon and Trazodone Combination Therapy for the Management of Delirium
Author(s): Takao Ishii*, Takafumi Morimoto, Masaki Shiraishi, Yoshiyasu Kigawa, Kenji Narita, Keisuke Inoue and Chiaki KawanishiTakao Ishii*, Takafumi Morimoto, Masaki Shiraishi, Yoshiyasu Kigawa, Kenji Narita, Keisuke Inoue and Chiaki Kawanishi
Background: Accumulating evidence supports the efficacy of antipsychotics in patients with delirium. However, extrapyramidal symptoms caused by antipsychotic medications represent a major concern in the pharmacotherapy of delirium, meaning that therapeutic alternatives using drugs other than antipsychotics are required. The aim of this study was to compare the efficacy and tolerability of trazodone monotherapy with ramelteon and trazodone combination therapy for the management of the symptoms of delirium. Methods: A case-control study was conducted in a general hospital setting. Delirium Rating Scale-revised-98 (DRS-R-98) scores were measured at the initial examination and at 3–7 days after starting the study drugs. Adverse drug reactions were also assessed. Results: Thirty-three patients were retrospectively enr.. View More»
DOI: 10.4172/2378-5756.1000444